Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres.

ABSTRACT:

Purpose

Glioblastoma (GBM) is the most aggressive type of brain tumor and has poor survival outcomes, even after a combination of surgery, radiotherapy, and chemotherapy. Temozolomide is the only agent that has been shown to be effective against GBM, suggesting that combination of temozolomide with other agents may be more effective. Niclosamide, an FDA approved anthelmintic agent, has shown anti-cancer effects against human colon, breast, prostate cancers as well as GBM. However, the efficacy of the combination of niclosamide with temozolomide against GBM tumorspheres (TSs) has not been determined. We hypothesized that the combined treatment could effectively suppress GBM TSs.

Methods

GBM TSs (TS15-88, GSC11) were treated with niclosamide and/or temozolomide. Combined effec

SUBMITTER: Oh HC 

PROVIDER: S-EPMC7519913 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature