COMUNET: a tool to explore and visualize intercellular communication.

ABSTRACT:

Motivation

Intercellular communication plays an essential role in multicellular organisms and several algorithms to analyze it from single-cell transcriptional data have been recently published, but the results are often hard to visualize and interpret.

Results

We developed Cell cOmmunication exploration with MUltiplex NETworks (COMUNET), a tool that streamlines the interpretation of the results from cell-cell communication analyses. COMUNET uses multiplex networks to represent and cluster all potential communication patterns between cell types. The algorithm also enables the search for specific patterns of communication and can perform comparative analysis between two biological conditions. To exemplify its use, here we apply COMUNET to investigate cell communication patter

SUBMITTER: Solovey M 

PROVIDER: S-EPMC7520036 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature