AOP4EUpest: mapping of pesticides in adverse outcome pathways using a text mining tool.

ABSTRACT:

Motivation

Exposure to pesticides may lead to adverse health effects in human populations, in particular vulnerable groups. The main long-term health concerns are neurodevelopmental disorders, carcinogenicity as well as endocrine disruption possibly leading to reproductive and metabolic disorders. Adverse outcome pathways (AOP) consist in linear representations of mechanistic perturbations at different levels of the biological organization. Although AOPs are chemical-agnostic, they can provide a better understanding of the Mode of Action of pesticides and can support a rational identification of effect markers.

Results

With the increasing amount of scientific literature and the development of biological databases, investigation of putative links between pesticides, from vari

SUBMITTER: Jornod F 

PROVIDER: S-EPMC7520043 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature