A model of twenty-three metabolic-related genes predicting overall survival for lung adenocarcinoma.

ABSTRACT:

Background

The highest rate of cancer-related deaths worldwide is from lung adenocarcinoma (LUAD) annually. Metabolism was associated with tumorigenesis and cancer development. Metabolic-related genes may be important biomarkers and metabolic therapeutic targets for LUAD.

Materials and methods

In this study, the gleaned cohort included LUAD RNA-SEQ data from the Cancer Genome Atlas (TCGA) and corresponding clinical data (n = 445). The training cohort was utilized to model construction, and data from the Gene Expression Omnibus (GEO, GSE30219 cohort, n = 83; GEO, GSE72094, n = 393) were regarded as a testing cohort and utilized for validation. First, we used a lasso-penalized Cox regression analysis to build a new metabolic-related signature for predictin

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC7520091 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature