Gene expression profile of adhesion and extracellular matrix molecules during early stages of skeletal muscle regeneration.

ABSTRACT: Skeletal muscle regeneration implies the coordination of myogenesis with the recruitment of myeloid cells and extracellular matrix (ECM) remodelling. Currently, there are no specific biomarkers to diagnose the severity and prognosis of muscle lesions. In order to investigate the gene expression profile of extracellular matrix and adhesion molecules, as premises of homo- or heterocellular cooperation and milestones for skeletal muscle regeneration, we performed a gene expression analysis for genes involved in cellular cooperation, migration and ECM remodelling in a mouse model of acute crush injury. The results obtained at two early time-points post-injury were compared to a GSE5413 data set from two other trauma models. Third day post-injury, when inflammatory cells invaded, genes associat

SUBMITTER: Ceafalan LC 

PROVIDER: S-EPMC7520258 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature