TOX correlates with prognosis, immune infiltration, and T cells exhaustion in lung adenocarcinoma.

ABSTRACT:

Background

Thymocyte selection-associated high mobility group box (TOX) plays a crucial role on the development of innate immunity and tumor microenvironment. This study aims to explore the prognostic potential of TOX and comprehensively analyze the correlations between TOX, immune infiltration, and T cells function in diverse cancers particularly lung adenocarcinoma (LUAD).

Methods

TIMER was used to analyze TOX expression in different cancers. Potential prognostic value of TOX was evaluated by the PrognoScan, Kaplan-Meier Plotter, and GEPIA2. The relationships between TOX, immune infiltration, and related gene marker sets were analyzed by TIMER and GEPIA2. Single-cell RNA-seq for T cells in LUAD was analyzed to further investigate the correlations between TOX expression and

SUBMITTER: Guo L 

PROVIDER: S-EPMC7520261 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature