Venous thromboembolism during preoperative chemotherapy in the CRITICS gastric cancer trial.

ABSTRACT:

Background

The occurrence of a venous thromboembolism (VTE) is common in patients with cancer. Gastric cancer has been associated with one of the highest risks for VTE. Chemotherapy, especially cisplatin has been associated with a high VTE risk. In this study, risk factors for VTE occurrence and their potential impact on subsequent therapeutic interventions were investigated in patients who underwent preoperative chemotherapy, in the CRITICS gastric cancer trial.

Patients and methods

Patients with resectable gastric cancer were preoperatively treated with three cycles of 3-weekly epirubicin, cisplatin or oxaliplatin, and capecitabine (ECC/EOC). VTE was defined as any thrombus in the venous system, excluding superficial and/or device related VTEs. Potential risk factors were

SUBMITTER: Slagter AE 

PROVIDER: S-EPMC7520268 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature