LncRNA-mRNA expression profiles and functional networks in osteoclast differentiation.

ABSTRACT: Human osteoclasts are differentiated from CD14⁺ monocytes and are responsible for bone resorption. Long non-coding RNAs (lncRNAs) have been proved to be significantly involved in multiple biologic processes, especially in cell differentiation. However, the effect of lncRNAs in osteoclast differentiation is less appreciated. In our study, RNA sequencing (RNA-seq) was used to identify the expression profiles of lncRNAs and mRNAs in osteoclast differentiation. The results demonstrated that expressions of 1117 lncRNAs and 296 mRNAs were significantly altered after osteoclast differentiation. qRT-PCR assays were performed to confirm the expression profiles, and the results were almost consistent with the RNA-seq data. GO and KEGG analyses were used to predict the functions of these d

SUBMITTER: Liu W 

PROVIDER: S-EPMC7520269 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature