SNP rs2243828 in MPO associated with myeloperoxidase level and atrial fibrillation risk in Chinese Han population.

ABSTRACT: Previous studies shown that myeloperoxidase (MPO) level is higher in patients with atrial fibrillation (AF); however, no genetic evidence between MPO and AF risk in human population was observed. Therefore, the present study was aimed to investigate the association between rs2243828, a variant in promoter region of MPO and the risk of AF in Chinese GeneID population. The results demonstrated that the minor G allele of rs2243828 showed a significant association with AF in two independent population (GeneID-north population with 694 AF cases and 710 controls, adjusted P_-adj = 6.25 × 10^-3 with an odds ratio was 0.77, GeneID-central population with 1106 cases and 1501 controls, P_-adj = 9.88 × 10^-5 with an odds ratio was 0.75). The results also showed

SUBMITTER: Wang P 

PROVIDER: S-EPMC7520285 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature