Aberrant ASPM expression mediated by transcriptional regulation of FoxM1 promotes the progression of gliomas.

ABSTRACT: Gliomas are the most common form of malignant tumour in the central nervous system. However, the molecular mechanism of the tumorigenesis and progression of gliomas remains unclear. In this study, we used the GEO database to identify genes differentially expressed in gliomas and predict the prognosis of glioma. We observed that ASPM mRNA was increased obviously in glioma tissue, and higher ASPM mRNA expression predicted worse disease prognosis. ASPM was highly expressed in glioma cell lines U87-MG and U251, and knockdown of ASPM expression in these cells significantly repressed the proliferation, migration and invasion ability and induced G0/G1 phase arrest. In addition, down-regulation of ASPM suppressed the growth of glioma in nude mice. Five potential binding sites for transcription fac

SUBMITTER: Zeng WJ 

PROVIDER: S-EPMC7520292 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature