Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor.

ABSTRACT: Liver cancer is the fastest growing cause of cancer deaths in the United States due to its aggressiveness and lack of effective therapies. The current preclinical study examines valeric acid (pentanoic acid [C₅H₁₀O₂]), one of the main compounds of valerian root extract, for its therapeutic use in liver cancer treatment. Anticancer efficacy of valeric acid was tested in a series of in vitro assays and orthotopic xenograft mouse models. The molecular target of valeric acid was also predicted, followed by functional confirmation. Valeric acid has a broad spectrum of anticancer activity with specifically high cytotoxicity for liver cancer in cell proliferation, colony formation, wound healing, cell invasion, and 3D spheroid formation assays. Mouse models

SUBMITTER: Han R 

PROVIDER: S-EPMC7520432 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature