A novel apoA-I mimetic peptide suppresses atherosclerosis by promoting physiological HDL function in apoE^-/- mice.

ABSTRACT:

Background and purpose

Apolipoprotein A-I (apoA-I) mimetic peptides (AAMPs) are short peptides that can mimic the physiological effects of apoA-I, including the suppression of atherosclerosis by reversely transporting peripheral cholesterol to the liver. As the hydrophobicity of apoA-I is considered important for its lipid transport, novel AAMPs were designed and synthesized in this study by gradually increasing the hydrophobicity of the parent peptide, and their anti-atherosclerotic effects were tested.

Experimental approach

Seventeen new AAMPs (P1-P17) with incrementally increased hydrophobicity were designed and synthesized by replacing the amino acids 221-240 of apoA-I (VLESFKVSFLSALEEYTKKL). Their effects on cholesterol efflux were evaluated. Their cytotoxicity and haem

SUBMITTER: Gou S 

PROVIDER: S-EPMC7520440 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature