Enhanced Klotho availability protects against cardiac dysfunction induced by uraemic cardiomyopathy by regulating Ca²⁺ handling.

ABSTRACT:

Background and purpose

Klotho is a membrane-bound or soluble protein, originally identified as an age-suppressing factor and regulator of mineral metabolism. Klotho deficiency is associated with the development of renal disease, but its role in cardiac function in the context of uraemic cardiomyopathy is unknown.

Experimental approach

We explored the effects of Klotho on cardiac Ca²⁺ cycling. We analysed Ca²⁺ handling in adult cardiomyocytes from Klotho-deficient (kl/kl) mice and from a murine model of 5/6 nephrectomy (Nfx). We also studied the effect of exogenous Klotho supplementation, by chronic recombinant Klotho treatment, or endogenous Klotho overexpression, using transgenic mice overexpressing Klotho (Tg-Kl), on uraemic cardiomyopathy. Hearts fro

SUBMITTER: Navarro-Garcia JA 

PROVIDER: S-EPMC7520447 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature