Phosphoregulation of the cytokinetic protein Fic1 contributes to fission yeast growth polarity establishment.

ABSTRACT: Cellular polarization underlies many facets of cell behavior, including cell growth. The rod-shaped fission yeast Schizosaccharomyces pombe is a well-established, genetically tractable system for studying growth polarity regulation. S. pombe cells elongate at their two cell tips in a cell cycle-controlled manner, transitioning from monopolar to bipolar growth in interphase when new ends established by the most recent cell division begin to extend. We previously identified cytokinesis as a critical regulator of new end growth and demonstrated that Fic1, a cytokinetic factor, is required for normal polarized growth at new ends. Here, we report that Fic1 is phosphorylated on two C-terminal residues, which are each targeted by multiple protein kinases. Endogenously expressed Fic1

SUBMITTER: Bohnert KA 

PROVIDER: S-EPMC7520453 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature