Circulating exosomal microRNAs as potential biomarkers of hepatic injury and inflammation in a murine model of glycogen storage disease type 1a.

ABSTRACT: Most patients affected by glycogen storage disease type 1a (GSD1a), an inherited metabolic disorder caused by mutations in the enzyme glucose-6-phosphatase-α (G6Pase-α), develop renal and liver complications, including the development of hepatocellular adenoma/carcinoma. The purpose of this study was to identify potential biomarkers of the pathophysiology of the GSD1a-affected liver. To this end, we used the plasma exosomes of a murine model of GSD1a, the LS-G6pc^-/- mouse, to uncover the modulation in microRNA expression associated with the disease. The microRNAs differentially expressed between LS-G6pc^-/- and wild-type mice, LS-G6pc^-/- mice with hepatocellular adenoma and LS-G6pc^-/- mice without adenoma, an

SUBMITTER: Resaz R 

PROVIDER: S-EPMC7520457 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature