Pediatric non-alcoholic fatty liver disease and kidney function: Effect of HSD17B13 variant.

ABSTRACT:

Background

Growing evidence supports a genetic link between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). Interesting data demonstrated that both the major NAFLD risk polymorphisms such as the I148M polymorphism in the patatin like phospholipase containing domain 3 (PNPLA3) and the E167K allele in the transmembrane 6 superfamily member 2 gene (TM6SF2) affect renal function. Recently the hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) gene has been recognized as a novel genetic variant involved in NAFLD pathophysiology. In particular, it has been showed the protective effect of the rs72613567:TA variant of this gene against liver damage both in adults and children.

Aim

To investigate the impact

SUBMITTER: Di Sessa A 

PROVIDER: S-EPMC7520609 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature