Photoprotective Potential of the Natural Artocarpin against In Vitro UVB-Induced Apoptosis.

ABSTRACT: Apoptosis, a well-known pattern of programmed cell death, occurs in multicellular organisms not only for controlling tissue homeostasis but also for getting rid of severely damaged cells in order to protect the redundant growth of abnormal cells undergoing cancerous cells. The epidermis of the human skin, composed largely of keratinocytes (KCs), is renewed continuously. Therefore, KCs apoptosis plays a critical role in the maintenance of epidermis structure and function. However, regulated cell death can be disturbed by environmental factors especially ultraviolet radiation (UV) B, leading to the formation of sunburn cells (KCs undergoing UVB-induced apoptosis) and impairing the skin integrity. In the present study, we firstly reported the potential of the natural artocarpin (NAR) to regul

SUBMITTER: Luangpraditkun K 

PROVIDER: S-EPMC7520682 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature