Comparison of phenylalanine tolerance in singleton and twin pregnancies in patients with phenylketonuria.

ABSTRACT:

Objectives

Empirical determination of phenylalanine (Phe) tolerance in patients with phenylketonuria (PKU) relies on frequent assessment of blood Phe concentrations in relation to Phe intake from detailed meal records. This study aimed to determine Phe tolerance in twin pregnancies.

Methods

The reviewed cases included three women with PKU who each had a singleton and twin pregnancy (i.e., they were pregnant twice). All patients were under regular supervision to maintain Phe concentrations in a steady state and determine safe Phe intake. Restriction of Phe in the patient's diet was determined depending on the amount of Phe intake, which allowed for stable blood Phe concentrations within the target range.

Results

In all three patients with PKU, the ratio of Phe toleranc

SUBMITTER: Hozyasz KK 

PROVIDER: S-EPMC7520934 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature