Tissue-specific usage of transposable element-derived promoters in mouse development.

ABSTRACT:

Background

Transposable elements (TEs) are a significant component of eukaryotic genomes and play essential roles in genome evolution. Mounting evidence indicates that TEs are highly transcribed in early embryo development and contribute to distinct biological functions and tissue morphology.

Results

We examine the epigenetic dynamics of mouse TEs during the development of five tissues: intestine, liver, lung, stomach, and kidney. We found that TEs are associated with over 20% of open chromatin regions during development. Close to half of these accessible TEs are only activated in a single tissue and a specific developmental stage. Most accessible TEs are rodent-specific. Across these five tissues, 453 accessible TEs are found to create the transcription start sites of downs

SUBMITTER: Miao B 

PROVIDER: S-EPMC7520981 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature