Small noncoding RNA sRNA0426 is involved in regulating biofilm formation in Streptococcus mutans.

ABSTRACT: Evidence suggests that small noncoding RNAs (sRNAs) are involved in the complex regulatory networks governing biofilm formation. Few studies have investigated the role of sRNAs in Streptococcus mutans (S. mutans). In the present study, the association between sRNA and biofilm formation in S. mutans was explored. sRNAs that are differentially expressed in the biofilm and planktonic states of this bacterium were identified by quantitative real-time PCR (qRT-PCR). Confocal laser scanning microscopy was used to investigate the characteristics of biofilm formation in a standard strain of S. mutans (UA159, ATCC 700610) and ten clinical strains. Bioinformatics analyses were employed to predict and examine potential sRNA regulatory pathways. The results showed that sRNA0426 has a strong positive r

SUBMITTER: Yin L 

PROVIDER: S-EPMC7521000 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature