CD14, CD163, and CCR1 are involved in heart and blood communication in ischemic cardiac diseases.

ABSTRACT:

Objective

Cardiac diseases lead to heart failure (HF), but the progression can take several years. Using blood samples to monitor changes in the heart before clinical symptoms begin may help to improve patient management.

Methods

Microarray data GSE42955 and GSE9128 were used as study datasets and GSE16499, GSE57338, and GSE59867 were used as validation groups. The "limma" package from R Language was used to identify differentially expressed genes. Functional enrichment analyses of gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways were performed using Database for Annotation, Visualization and Integrated Discovery. We also investigated the correlation between the heart and blood using the mRNA expression level.

Results

Three hub genes, CD14, CD1

SUBMITTER: Chen C 

PROVIDER: S-EPMC7521061 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature