Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis.

ABSTRACT:

Objective

To examine incidences and risk factors for metachronous vulvar, vaginal, and anal malignancies after a cervical cancer diagnosis.

Methods

This is a retrospective study examining data from the Surveillance, Epidemiology, and End Result Program between 1973 and 2013. Cumulative incidences of vulvar, vaginal, and anal cancers after the diagnosis of cervical cancer were assessed (n = 79,050). Multivariable analysis was performed to determine independent risk factors for these metachronous cancers.

Results

Vaginal cancer (20-year cumulative incidence, 0.57%) was the most common type of metachronous malignancy, followed by vulvar cancer (0.33%), and anal cancer (0.16%, P < 0.001). Median time to diagnosis was 5.4 years for vaginal cancer, 6.5 years for vulvar canc

SUBMITTER: Matsuo K 

PROVIDER: S-EPMC7521078 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature