Route-specific association of progestin therapy and concurrent metformin use in obese women with complex atypical hyperplasia.

ABSTRACT:

Introduction

Previous studies have suggested that metformin use may enhance the therapeutic effect of progestin therapy for endometrial hyperplasia or malignancy. However, it is not known how the impact of concurrent metformin may be altered by route of progestin therapy, either locally via an intrauterine device or systemically. This study examined the effectiveness of concurrent metformin use and progestin therapy for women with complex atypical hyperplasia stratified by progestin route (systemic vs local).

Methods

This single-institution retrospective study examined consecutive women with complex atypical hyperplasia who received progestin therapy from 2003 to 2018. Time-dependent analyses for complete response rate were performed comparing concurrent metformin users vers

SUBMITTER: Matsuo K 

PROVIDER: S-EPMC7521080 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature