Proposal for a Risk-Based Categorization of Uterine Carcinosarcoma.

ABSTRACT: PURPOSE:To propose a categorization model of uterine carcinosarcoma (UCS) based on tumor cell types (carcinoma and sarcoma) and sarcoma dominance. METHODS:This secondary analysis of a prior multicenter retrospective study examined 889 cases of UCS with available histologic evaluation. Based on survival outcome, cases were clustered into three groups: low-grade carcinoma with nondominant homologous sarcoma [type A, n?=?96 (10.8%)], (1) low-grade carcinoma with heterologous sarcoma or any sarcoma dominance and (2) high-grade carcinoma with nondominant homologous sarcoma [type B, n?=?412 (46.3%)], and high-grade carcinoma with heterologous sarcoma or any sarcoma dominance [type C, n?=?381 (42.9%)]. Tumor characteristics and outcome were examined based on the categorization. RESULTS:Women in type C category were more likely to be older, obese, and Caucasian, whereas those in type A category were younger, less obese, Asian, and nulligravid (all P?

SUBMITTER: Matsuo K 

PROVIDER: S-EPMC7521084 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature