Life course trajectories of cardiovascular risk: Impact on atherosclerotic and metabolic indicators.

ABSTRACT:

Background and aims

In this analysis, we estimated population-level trajectory groups of life course cardiovascular risk to explore their impact on mid-life atherosclerotic and metabolic outcomes.

Methods

This prospective study followed n = 1269 Bogalusa Heart participants, each with at least 4 study visits from childhood in 1973 through adulthood in 2016. We used discrete mixture modeling to determine trajectories of cardiovascular risk percentiles from childhood to adulthood. Outcomes included mid-life subclinical atherosclerotic measures [(carotid intima-media thickness (cIMT), pulse wave velocity (PWV)], metabolic indicators [(diabetes and body mass index (BMI)], and short physical performance battery (SPPB).

Results

Between the mean ages of 9.6-48.3 years, we est

SUBMITTER: Pollock BD 

PROVIDER: S-EPMC7521150 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature