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ABSTRACT: Aim
There are limited data describing incidence of symptomatic venous thromboembolism (VTE) in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) patients receiving peg-asparaginase.Materials & methods
Single-institution retrospective analysis of 44 AYA ALL patients treated with peg-asparaginase. Rates of VTE and proposed risk factors were assessed.Results
18 patients (41%) had a symptomatic VTE following peg-asparaginase. The cumulative incidence rate was 25% (95% CI: 13-38%) within 30 days of the initial dose. Personal history of thrombosis was statistically significantly associated with an increased risk of VTE with HR of 2.73 (95% CI: 1.40-5.33, p = 0.003) after adjusting for gender.Conclusion
These data indicate a high rate of VTE in the AYA ALL population following treatment with peg-asparaginase.
SUBMITTER: Underwood B
PROVIDER: S-EPMC7521187 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Underwood Brynne B Zhao Qiuhong Q Walker Alison R AR Mims Alice S AS Vasu Sumithira S Long Meixiao M Z Haque Tamanna T Blaser Bradley W BW Grieselhuber Nicole R NR Wall Sarah A SA Behbehani Gregory K GK Blachly James S JS Larkin Karilyn K Byrd John C JC Garzon Ramiro R Wang Tzu-Fei TF Bhatnagar Bhavana B
International journal of hematologic oncology 20200904 3
<h4>Aim</h4>There are limited data describing incidence of symptomatic venous thromboembolism (VTE) in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) patients receiving peg-asparaginase.<h4>Materials & methods</h4>Single-institution retrospective analysis of 44 AYA ALL patients treated with peg-asparaginase. Rates of VTE and proposed risk factors were assessed.<h4>Results</h4>18 patients (41%) had a symptomatic VTE following peg-asparaginase. The cumulative incidence rate wa ...[more]