Association between variants in vitamin D-binding protein gene and vitamin D deficiency among pregnant women in china.

ABSTRACT:

Background

The prevalence of vitamin D deficiency and insufficiency is extremely high in pregnant women worldwide. However, the association between single nucleotide polymorphisms (SNPs) in vitamin D metabolic pathway genes and 25-hydroxyvitamin D (25(OH)D) concentration among Chinese pregnant women is seldom reported. The risk of adverse neonatal outcomes due to maternal vitamin D deficiency has not been well investigated.

Methods

A total of 815 pregnant women and 407 infants were enrolled in this study. Serum 25(OH)D concentration was detected. DNA was extracted from the maternal blood for genotyping genetic SNPs in vitamin D pathway. An XGBoost model was established based on SNPs combined with external variables.

Results

Mean serum 25(OH)D level was 15.67 ± 7.98 ng

SUBMITTER: Dong J 

PROVIDER: S-EPMC7521226 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature