PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case-control study.

ABSTRACT:

Background

Several studies probed into the connection between esophageal cancer (EC) risk and PRKAA1 rs13361707 C/T polymorphism, but obtained insignificant findings.

Methods

In this study, 814 EC cases and 961 controls from Eastern China were recruited to validate the relationship between this polymorphism and EC susceptibility.

Results

Data suggested rs13361707 C/T polymorphism in PRKAA1 gene was significantly related with a lower risk for EC. Such significant connection was also uncovered in subgroups of males, smokers, drinkers and individuals with age ≥ 60 years. In addition, this polymorphism was linked with the pathological grading, distant metastasis, and histology of EC.

Conclusion

In summary, PRKAA1 rs13361707 C/T polymorphism is related to the risk a

SUBMITTER: Li CL 

PROVIDER: S-EPMC7521242 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature