Evidence of mesenchymal stromal cell adaptation to local microenvironment following subcutaneous transplantation.

ABSTRACT: Subcutaneous transplantation of mesenchymal stromal cells (MSC) emerged as an alternative to intravenous administration because it avoids the pulmonary embolism and prolongs post-transplantation lifetime. The goal of this study was to investigate the mechanisms by which these cells could affect remote organs. To this aim, murine bone marrow-derived MSC were subcutaneously transplanted in different anatomical regions and the survival and behaviour have been followed. The results showed that upon subcutaneous transplantation in mice, MSC formed multicellular aggregates and did not migrate significantly from the site of injection. Our data suggest an important role of hypoxia-inducible signalling pathways in stimulating local angiogenesis and the ensuing modulation of the kinetics of circulat

SUBMITTER: Preda MB 

PROVIDER: S-EPMC7521285 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature