Increased CCL24 and CXCL7 levels in the cerebrospinal fluid of patients with neurosyphilis.

ABSTRACT:

Background

Monocytes are recruited into the cerebrospinal fluid (CSF) of patients with neurosyphilis, suggesting abnormal chemokine expression. We aimed to investigate the aberrant expression of chemokines in the CSF of these patients.

Methods

CSF and serum samples were collected from patients with neurosyphilis between July 2017 and June 2019 in the Dermatology Department, Second Affiliated Hospital of Zhejiang University. Differences in the expression of 38 chemokines between patients with and without neurosyphilis were detected using RayBio^® Human Chemokine Antibody Array C1. CCL24 and CXCL7 levels in the patients' CSF and serum were further measured using RayBio^® CCL24 and CXCL7 ELISA kits.

Results

Ninety-three CSF and serum samples of patien

SUBMITTER: Li XX 

PROVIDER: S-EPMC7521312 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature