Effects of Xeroderma pigmentosum group C polymorphism on the likelihood of prostate cancer.

ABSTRACT:

Background

Numerous studies have assessed the association between xeroderma pigmentosum complementation group C (XPC) polymorphisms and susceptibility of prostate cancer (PCa); however, the findings remain inconsistent.

Methods

We performed an updated analysis utilizing data from electronic databases to obtain a more accurate estimation of the relationship between XPC rs2228001 A/C polymorphism and PCa risk. We further used in silico tools to investigate this correlation.

Results

Totally, 5,305 PCa cases and 6,499 control subjects were evaluated. When all studies pooled together, we detected no positive result (recessive genetic model: OR = 1.14, 95% CI = 0.93-1.40, P_{heterogeneity}  = 0.001, P = .212); nevertheless, the XPC rs2228001 A/C variant was associat

SUBMITTER: Yan Y 

PROVIDER: S-EPMC7521337 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature