Ontology highlight
ABSTRACT:
SUBMITTER: Ha CWY
PROVIDER: S-EPMC7521382 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cell 20200928 3
A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of "creeping fat" (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and fibrotic intestine. In the current study, we explore whether microbial translocation in CD serves as a central cue for CrF development. We discovered a subset of mucosal-associated gut bacteria that consistently translocated and remained viable in CrF in CD ileal surgical resections, and identified Clostridium innocu ...[more]