Oxidative stress, apoptosis and inflammatory responses involved in copper-induced pulmonary toxicity in mice.

ABSTRACT: At present, there are few studies focused on the relationship between copper (Cu) and oxidative stress, apoptosis, or inflammatory responses in animal and human lungs. This study was conducted to explore the effects of Cu on pulmonary oxidative stress, apoptosis and inflammatory responses in mice orally administered with 0 mg/kg (control), 10 mg/kg, 20 mg/kg, and 40 mg/kg of CuSO₄ for 42 days. The results showed that CuSO₄ increased ROS production, and MDA, 8-OHdG and NO contents as well as iNOS activities and mRNA expression levels. Meanwhile, CuSO₄ reduced the activities and mRNA expression levels of antioxidant enzymes (GSH-Px, CAT, and SOD) and GSH contents, and ASA and AHR abilities. Also, CuSO₄ induced apoptosis, which was accompanied by de

SUBMITTER: Jian Z 

PROVIDER: S-EPMC7521514 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature