PGC-1α and ERRα in patients with endometrial cancer: a translational study for predicting myometrial invasion.

ABSTRACT:

Background

PGC-1α and ERRα are closely related to tumor formation and progression. However, the mechanism underlying the involvement of PGC-1α/ERRα in regulating invasion and migration in endometrial cancer remains to be explored.

Results

Elevated levels of PGC-1α and ERRα were associated with advanced myometrial invasion, and PGC-1α and Vimentin expression was related to the depth of myometrial invasion in premenopausal endometrial cancer. Silencing of PGC-1α reduced ERRα activation and inhibited epithelial-mesenchymal-transition phenotypes, resulting in significant inhibition of invasion and migration. Overexpression of ERRα led to enhanced PGC-1α expression and increased activity of TFEB, promoting epithelial-mesenchymal-transition in endometrial cancer cells.

Conclusi

SUBMITTER: Chen L 

PROVIDER: S-EPMC7521515 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature