Discovering correlates of age-related decline in a healthy late-midlife male birth cohort.

ABSTRACT: Studies exploring age-related brain and cognitive change have identified substantial heterogeneity among individuals, but the underlying reasons for the differential trajectories remain largely unknown. We investigated cross-sectional and longitudinal associations between brain-imaging phenotypes (IDPs) and cognitive ability, and how these relations may be modified by common risk and protective factors. Participants were recruited from the 1953 Danish Male Birth Cohort (N=123), a longitudinal study of cognitive and brain ageing. Childhood IQ and socio-demographic factors are available for these participants who have been assessed regularly on multiple IDPs and behavioural factors in midlife. Using Pearson correlations and canonical correlation analysis (CCA), we explored the relation betwe

SUBMITTER: Zarnani K 

PROVIDER: S-EPMC7521526 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature