Annotation of susceptibility SNPs associated with atrial fibrillation.

ABSTRACT:

Objective

Genome-wide association studies (GWAS) and the candidate gene based association studies have identified a panel of variants associated with atrial fibrillation (AF), however, most of the identified single nucleotide polymorphisms (SNPs) were found located within intergenic or intronic genomic regions, and whether the positive SNPs have a real biological function is unknown, and the real disease causing gene need to be studied.

Results

The current results of the genetic studies including common variants identified by GWAS (338 index SNPs) and candidate gene based association studies (40 SNPs) were summarized.

Conclusion

Our study suggests the relationship between genetic variants and possible targeted genes, and provides insight into potential genetic pathway

SUBMITTER: Xu C 

PROVIDER: S-EPMC7521544 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature