Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented <i>APOE</i> ε4 carriers.

ABSTRACT:

Introduction

The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic-memory decline in non-demented individuals remains unclear.

Methods

We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)-derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European Lifebrain consortium.

Results

The change-change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, P = .007; non-carriers: N = 467, r = 0.073, P = .117). The linear relations

SUBMITTER: Gorbach T 

PROVIDER: S-EPMC7521596 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature