Dataset Information

Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers.

ABSTRACT:

Introduction

The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic-memory decline in non-demented individuals remains unclear.

Methods

We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)-derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European Lifebrain consortium.

Results

The change-change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, P = .007; non-carriers: N = 467, r = 0.073, P = .117). The linear relationship was significantly steeper for the carriers [t(629) = 2.4, P = .013]. A similar trend toward a stronger change-change relation for carriers was seen in a subsample with more than two assessments.

Discussion

These findings provide evidence for a difference in hippocampus-memory association between ε4 carriers and non-carriers, thus highlighting how genetic factors modulate the translation of the AD-related pathophysiological cascade into cognitive deficits.

SUBMITTER: Gorbach T

PROVIDER: S-EPMC7521596 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented <i>APOE</i> ε4 carriers.

Gorbach Tetiana T Pudas Sara S Bartrés-Faz David D Brandmaier Andreas M AM Düzel Sandra S Henson Richard N RN Idland Ane-Victoria AV Lindenberger Ulman U Macià Bros Didac D Mowinckel Athanasia M AM Solé-Padullés Cristina C Sørensen Øystein Ø Walhovd Kristine B KB Watne Leiv Otto LO Westerhausen René R Fjell Anders M AM Nyberg Lars L

Alzheimer's & dementia (Amsterdam, Netherlands) 20200928 1

<h4>Introduction</h4>The apolipoprotein E (<i>APOE</i>) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic-memory decline in non-demented individuals remains unclear.<h4>Methods</h4>We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)-derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 ye ...[more]

PMID: 33015312

Similar Datasets

Project description:BackgroundSubjective cognitive decline (SCD) is characterized by self-reported cognitive deficits without measurable cognitive impairment. It has been suggested that individuals with SCD exhibited brain structural alterations in widespread cortical thinning or gray matter loss in the medial temporal and frontotemporal regions. Apolipoprotein E (APOE) ε4 allele is thought to be a genetic marker associated with risk of SCD. Neuropsychiatric symptoms may provide insight in detecting higher-risk elders for early Alzheimer's disease as well. Therefore, we aim to explore the characteristics of brain morphology in SCD and to determine whether it is influenced by APOE ε4 as well as neuropsychiatric symptoms in SCD.MethodsA total of 138 cognitively normal older individuals from the SILCODE cohort underwent a clinical interview, neuropsychological assessments, a blood test, and MRI. A two-sample t-test was used to examine the cortex volume and bilateral cortical surface area alterations between SCD (n = 65) and controls (n = 73). A general linear model analysis was used to test for both main and interaction effects of clinical phenotype (SCD vs. controls) and APOE on global and regional cortex volume and bilateral cortical surface area and thickness. A multiple linear regression analysis was conducted to determine the effects of the APOE genotype on the relationships between morphometric features and neuropsychiatric symptoms in SCD.ResultsCompared with controls, individuals with SCD showed decreased total cortical volumes and cortical surface area. SCD APOE ε4 carriers showed additive reduction in the right cortical surface area. The evaluation scores of anxiety symptoms were negatively associated with the right cortical surface area in SCD APOE 4 non-carriers.ConclusionsIndividuals with SCD had an altered cortical surface area, and APOE genotype and anxiety symptoms are modified factors on the cortical surface area decrease in SCD.Trial registrationClinicalTrials.gov (Identifier: NCT03370744 ). Registered 15 March 2017.

Dataset Information

Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers.

Introduction

Methods

Results

Discussion

Publications

Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented <i>APOE</i> ε4 carriers.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers.

Introduction

Methods

Results

Discussion

Publications

Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented &lt;i&gt;APOE&lt;/i&gt; ε4 carriers.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented <i>APOE</i> ε4 carriers.