Epithelial tissue geometry directs emergence of bioelectric field and pattern of proliferation.

ABSTRACT: Patterns of proliferation are templated by both gradients of mechanical stress as well as by gradients in membrane voltage (Vm), which is defined as the electric potential difference between the cytoplasm and the extracellular medium. Either gradient could regulate the emergence of the other, or they could arise independently and synergistically affect proliferation within a tissue. Here, we examined the relationship between endogenous patterns of mechanical stress and the generation of bioelectric gradients in mammary epithelial tissues. We observed that the mechanical stress gradients in the tissues presaged gradients in both proliferation and depolarization, consistent with previous reports correlating depolarization with proliferation. Furthermore, disrupting the Vm gradient blocked th

SUBMITTER: Silver BB 

PROVIDER: S-EPMC7521849 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature