An Update on [¹⁸F]Fluoride PET Imaging for Atherosclerotic Disease.

ABSTRACT: Atherosclerosis is the leading cause of life-threatening morbidity and mortality, as the rupture of atherosclerotic plaques leads to critical atherothrombotic events such as myocardial infarction and ischemic stroke, which are the 2 most common causes of death worldwide. Vascular calcification is a complicated pathological process involved in atherosclerosis, and microcalcifications are presumed to increase the likelihood of plaque rupture. Despite many efforts to develop novel non-invasive diagnostic modalities, diagnostic techniques are still limited, especially before symptomatic presentation. From this point of view, vulnerable plaques are a direct target of atherosclerosis imaging. Anatomic imaging modalities have the limitation of only visualizing macroscopic structural changes, whic

SUBMITTER: Lee R 

PROVIDER: S-EPMC7521973 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature