Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia.

ABSTRACT:

Introduction

Acute lymphoblastic leukemia (ALL) therapy confers risk for venous thromboembolism (VTE) and associated acute and long-term morbidity. Obesity increases VTE risk in the general population but its impact on ALL therapy-associated VTE is unknown.

Methods

In a retrospective cohort of children treated for ALL between 2008 and 2016 (n = 294), we analyzed obesity at diagnosis (body mass index [BMI] ≥95%) and subsequent development of VTE. A subset participated in two concurrent prospective ALL trials studying body composition via dual-energy X-ray absorptiometry (DXA) (n = 35) and hypercoagulability via thromboelastography (TEG) (n = 46). Secondary analyses explored whether precise measurement of body fat and/or global hemostasis ex vivo by TEG could further delineate

SUBMITTER: Prasca S 

PROVIDER: S-EPMC7522001 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature