Structural and functional comparison of Saccharomonospora azurea strains in terms of primycin producing ability.

ABSTRACT: Emerging and re-emerging microbial pathogens, together with their rapid evolution and adaptation against antibiotics, highlight the importance not only of screening for new antimicrobial agents, but also for deepening knowledge about existing antibiotics. Primycin is a large 36-membered non-polyene macrolide lactone exclusively produced by Saccharomonospora azurea. This study provides information about strain dependent primycin production ability in conjunction with the structural, functional and comparative genomic examinations. Comparison of high- and low-primycin producer strains, transcriptomic analysis identified a total of 686 differentially expressed genes (DEGs), classified into diverse Cluster of Orthologous Groups. Among them, genes related to fatty acid synthesis, self-resistanc

SUBMITTER: Kovacs M 

PROVIDER: S-EPMC7522111 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature