Revised annotation and extended characterizations of components of the Chlamydomonas reinhardtii SUMOylation system.

ABSTRACT: Small ubiquitin-like modifier (SUMO) conjugation, or SUMOylation, is a reversible post-translational modification that is important for regulation of many cellular processes including cell division cycle in the eukaryotic kingdom. However, only a portion of the components of the Chlamydomonas SUMOylation system are known and their functions and regulation investigated. The present studies are aimed at extending discovery and characterization of new components and improving the annotation and nomenclature of all known proteins and genes involved in the system. Even though only one copy of the heterodimerized SUMO-activating enzyme, SAE1 and SAE2, was identified, the number of SUMO-conjugating enzymes (SCEs) and SUMO proteases/isopeptidase was expanded in Chlamydomonas.

SUBMITTER: Lin YL 

PROVIDER: S-EPMC7522501 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature