Association of corticosteroids use and outcomes in COVID-19 patients: A systematic review and meta-analysis.

ABSTRACT:

Background

To systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients.

Methods

We searched Medline, Embase, EBM Reviews, Scopus, Web of Science, and preprints up to July 20, 2020. We included observational studies and randomized controlled trials (RCT) that assessed COVID-19 patients treated with CST. We pooled adjusted effect estimates of mortality and other outcomes using a random effect model, among studies at low or moderate risk for bias. We assessed the certainty of evidence for each outcome using the GRADE approach.

Results

Out of 1067 citations screened for eligibility, one RCT and 19 cohort studies were included (16,977 hospitalized patients). Ten studies (1 RCT and 9 cohorts)

SUBMITTER: Tlayjeh H 

PROVIDER: S-EPMC7522674 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature