Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome.

ABSTRACT:

Importance

Risk of Alzheimer disease (AD) is particularly high for individuals with Down syndrome (DS). The ε4 allele of the apolipoprotein E gene (APOE ε4) is associated with an additional risk for AD. In typical development, there is evidence that the APOE ε4 genotype is associated with an early cognitive advantage. Here we investigate associations of APOE ε4 with attention across the life span of individuals with DS.

Objective

To investigate associations between APOE ε4 and attentional abilities in young children and in adults with DS.

Design, settings, and participants

In this cross-sectional study, data were collected from 80 young children with DS (8-62 months of age) and 240 adults with DS (16-71 years of age) during the period from 2013 to 2018 at a research c

SUBMITTER: D'Souza H 

PROVIDER: S-EPMC7522696 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature