Early Gluten Introduction and Celiac Disease in the EAT Study: A Prespecified Analysis of the EAT Randomized Clinical Trial.

ABSTRACT:

Importance

There are no strategies for the prevention of celiac disease (CD). Current guidelines stating that the age at gluten introduction does not affect the prevalence of CD are based on the results from several randomized clinical trials, but the doses of gluten and timing of its introduction varied.

Objective

To determine whether early introduction of high-dose gluten lowers the prevalence of CD at age 3 years.

Design, setting, and participants

The Enquiring About Tolerance (EAT) Study was an open-label randomized clinical trial. A total of 1303 children from the general population in England and Wales were recruited and followed up from November 2, 2009, to July 30, 2012. For the present study, samples were collected from November 1, 2012, to March 31, 2015, an

SUBMITTER: Logan K 

PROVIDER: S-EPMC7522778 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature