Circulating microRNAs in serum as novel biomarkers for osteoporosis: a case-control study.

ABSTRACT:

Aims

Osteoporosis is underdiagnosed because of the lack of a convenient diagnostic method. Circulating microRNAs (miRNAs) emerge as novel biomarkers for disease diagnosis. Here, we conducted a case-control study that included a total of 448 serum samples collected from 182 healthy participants, 132 osteopenia participants, and 134 osteoporosis patients.

Methods

Circulating miRNAs dysregulated during osteoporosis were screened and analyzed in three randomly determined sub-cohorts: the discovery cohort identified 22 candidate miRNAs; the training cohort tested the candidate miRNAs and constructed Index 1, comprising five miRNAs by logistic regression, and Index 2, comprising four miRNAs, was developed by linear combination.

Results

Both indices were tested in the valida

SUBMITTER: Shuai Y 

PROVIDER: S-EPMC7522822 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature