High-flow nasal oxygen reduces endotracheal intubation: a randomized clinical trial.

ABSTRACT:

Background

The benefits of high-flow nasal cannula (HFNC) as primary intervention in patients with acute hypoxemic respiratory failure (AHRF) are still a matter in debate. Our objective was to compare HFNC therapy versus conventional oxygen therapy (COT) in the prevention of endotracheal intubation in this group of patients.

Methods

An open-label, controlled and single-centre clinical trial was conducted in patients with severe AHRF, defined by a PaO₂/FIO₂ ratio ⩽200, to compare HFNC with a control group (CG) treated by COT delivered through a face mask, with the need to perform intubation as the primary outcome. The secondary outcomes included tolerance of the HFNC device and to look for the predictive factors for intubation in these patients.

SUBMITTER: Andino R 

PROVIDER: S-EPMC7522841 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature