Mild hypercapnia improves brain tissue oxygen tension but not diffusion limitation in asphyxial cardiac arrest: an experimental study in pigs.

ABSTRACT:

Background

We sought to evaluate the effect of mild hypercapnia on brain tissue oxygen tension (Pbto₂) and diffusion limitation (impaired ability of oxygen extraction) in a porcine post asphyxial cardiac arrest model.

Methods

In 16 Bama pigs, asphyxial cardiac arrest was induced by endotracheal tube clamping and remained untreated for another 4 min. After return of spontaneous circulation (ROSC), animals were randomly assigned to mild hypercapnia (end-tidal carbon dioxide (EtCO₂): 45 ~ 50 mmHg) and normocapnia (EtCO₂: 35 ~ 40 mmHg) groups for 12 h. Intracranial pressure (ICP), Pbto₂, and brain tissue temperature were invasively measured by multimodality monitors. Blood gas analysis, neuron specific enolase (NSE), and S100β were tes

SUBMITTER: Zhou D 

PROVIDER: S-EPMC7522908 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature