Epinephrine's effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation.

ABSTRACT:

Background

Despite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenation, possibly potentiating neurological injury during CPR. We investigated the cerebrovascular effects of intravenous epinephrine in a swine model of pediatric in-hospital cardiac arrest. The primary objectives of this study were to determine if (1) epinephrine doses have a significant acute effect on CBF and cerebral tissue oxygenation during CPR and (2) if the effect of each subsequent dose of epinephrine differs significantly from that of the first.

Methods

One-month-old piglets (n = 20) underwent asphyxia for 7 min, ventricular fibrillation, and CPR for 10

SUBMITTER: Mavroudis CD 

PROVIDER: S-EPMC7522922 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature