Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis.

ABSTRACT: The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against Mycobacterium smegmatis. As a result, we discovered several analogues that both inhibit and disperse M. smegmatis biofilms.

SUBMITTER: Brackett SM 

PROVIDER: S-EPMC7523022 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature